CASE REPORT

Fatal anaphylactoid reaction to N-acetylcysteine: caution in patients with asthma

A V Appelboam¹, P I Dargan², J Knighton¹

¹ Queen Alexandra Hospital, Portsmouth, UK
² National Poisons Information Service, London, UK

Correspondence to:
Correspondence to:
Dr A Appelboam, Department of Anaesthetics, Torbay Hospital, Torquay, Devon TQ2 7AA;
andy.bec{at}virgin.net

Paracetamol overdose is a common reason for presentation to the emergency department and N-acetylcysteine is frequently used in the treatment of toxic paracetamol ingestions. Adverse reactions to N-acetylcysteine are common though usually mild and easily treated. Serious reactions to N-acetylcysteine however, are rare and there have been no previous reported fatalities with its therapeutic use. This report describes the case of a 40 year old brittle asthmatic patient who died after treatment with intravenous N-acetylcysteine. Asthma is a risk factor for adverse reactions to N-acetylcysteine and special caution should be exercised in its use in brittle asthmatic patients.

Keywords: paracetamol; asthma; N-acetylcysteine

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