© 2003 BMJ Publishing Group, British Association for Accident & Emergency Medicine, & Faculty of Accident & Emergency Medicine
CASE REPORT
Transient lupus anticoagulant: an unusual cause of bruising in children
1 Department of Paediatrics, Hemel Hempstead General Hospital, UK
2 Department of Paediatric Haematology, Great Ormond Street Hospital, London, UK
Correspondence to:
Correspondence to:
Dr A-K Anderson, 20 Kendal Close, London SW9 6EW, UK;
annakarenia{at}netscape.net
A child presented with excessive bruising and prolonged activated partial thromboplastin time. Mixing studies in plasma were positive for phospholipid dependence of the anticoagulant, confirming a diagnosis of lupus anticoagulant. Factor II level was reduced. Laboratory findings normalised after three months, with spontaneous resolution of bruising. This case demonstrates a transient antiphospholipid antibody syndrome as a rare presentation of bleeding diathesis in a previously healthy child, and should be considered in children with new onset bruising and prolonged activated partial thromboplastin time.
Keywords: lupus anticoagulant; coagulation; bleeding diathesis
Abbreviations: aPTT, activated partial thromboplastin time; LA, lupus anticoagulant; APA, antiphospholipid antibody
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