© 2004 BMJ Publishing Group Ltd, British Association for Accident & Emergency Medicine, & Faculty of Accident & Emergency Medicine
CASE REPORT
Propofol combined with lorazepam for severe poly substance misuse and withdrawal states in intensive care unit: a case series and review
Long Island College Hospital, Brooklyn, NY, USA
Correspondence to:
Correspondence to:
Dr K Subramaniam
Beth Israel Deaconess Medical Center, Department of Anesthesia and Critical Care, 330 Brookline Avenue, Boston, 02215, USA; kathirvels{at}yahoo.com
A safe, rapid, and effective way to detoxify patients from substance misuse is important in facilitating further treatment of their psychiatric or substance use disorder. This paper discusses the treatment of acute withdrawal from polysubstance misuse in three patients in the intensive care unit setting using combined sedation with a benzodiazepine, lorazepam, and a general anaesthetic, propofol. Lorazepam alone was not effective in massive doses in these cases. The advantages and mechanism of action of using multiple agents to control refractory symptoms is discussed.
Abbreviations: ICU, intensive care unit; DT, delirium tremens
Keywords: polysubstance misuse; propofol; lorazepam; withdrawal syndromes
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