CASE REPORT
Two cases of retroperitoneal haematoma caused by interaction between antibiotics and warfarin
Department of Surgery, Royal Surrey County Hospital, Egerton Road, Guildford, Surrey, UK
Correspondence to:
Correspondence to:
Dr S Phillips
Department of Surgery, Royal Surrey County Hospital, Egerton Road, Guildford, Surrey GU2 7XX, UK; drsimonphillips{at}hotmail.com
Several commonly prescribed antibiotics are known to interact with warfarin, increasing its anticoagulant effect by different mechanisms. Retroperitoneal bleeding with consequent haematoma is recognised as a complication of over-anticoagulation. Consequences, which are potentially fatal, include hypovolaemic shock and compression of retroperitoneal structures such as the ureter and inferior vena cava.
Abbreviations: CT, computed tomography; INR, international normalised ratio; IVC, inferior vena cava; PE, pulmonary embolism
Keywords: Antibiotic; complication; haematoma; retroperitoneal; warfarin
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