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Stability of succinylcholine solutions stored at room temperature studied by nuclear magnetic resonance spectroscopy

¹ SAMU 93 – EA 3409, Hopital Avicenne, Bobigny Cedex, France
² UMR CNRS 1430; UFR SMBH, Bobigny Cedex, France
³ Department of Anesthesiology, MetroHealth Medical Center, Cleveland, Ohio, USA

Correspondence to:
Correspondence to:
Professor Frédéric Adnet
SAMU 93 – EA 3409, Hôpital Avicenne, 125, Rue de Stalingrad, 93009 Bobigny Cedex, France; frederic.adnet{at}avc.aphp.fr

The effect of storage temperature on the stability of two succinylcholine chloride solutions (20 and 50 mg/ml) was evaluated. Molecular composition was analysed using nuclear magnetic resonance spectroscopy. At room temperature, the degradation rate constant was 1.2%/month for the 20 mg/ml solution and 2.1%/month for the 50 mg/ml solution. The corresponding monthly degradation rates for the two solutions were 0.18% and 0.30% when stored at 4°C, and 5.4% and 8.1% when stored at 37°C. If a 10% loss of potency is considered acceptable, then the 20 and 50 mg/ml succinylcholine solutions can be stored in emergency resuscitation carts at room temperature for 8.3 and 4.8 months, respectively.