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Emergency Medicine Journal 2007;24:e18; doi:10.1136/emj.2006.042887
© 2007 BMJ Publishing Group Ltd and the College of Emergency Medicine.

EMERGENCY CASEBOOK

Beware of prosthetic valve thrombosis despite therapeutic anticoagulation

Paul William Xavier Foley1, Raj Sharma2 and Paul R Karla1

1 St Mary’s Hospital, Portsmouth, Hampshire, UK
2 Department of Cardiology, Ealing District Hospital and Hammersmith Hospital, Ealing Hospital NHS Trust, Southall, London, UK

Correspondence to:
Correspondence to:
Dr P W X Foley
St Mary’s Hospital, Milton Road, Portsmouth PO6 3AD, UK; paulfoley{at}talk21.com

ABSTRACT

Patients with mechanical heart valves require anticoagulation within carefully controlled ranges to prevent valve thrombosis, a life-threatening condition. The majority of doctors will be required to manage anticoagulation, often on a temporary basis such as during elective procedures. As long-term anticoagulation management moves away from specialised hospital clinics, there needs to be widespread awareness of the complications of sub-therapeutic international normalised ratios (INRs).

Abbreviations: INR, international normalised ratio; PVT, prosthetic valve thrombosis


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