ORIGINAL ARTICLES
Serum adenosine deaminase levels in diagnosis of acute appendicitis
Z A Öztürk1,
S Köklü2,
M F Erol3,
F M Y
lmaz4,
Ö Ba
ar5,
O Yüksel6,
G Ylmaz4,
B Ksack7 and
Yüksel5
1 Department of Internal Medicine, Ankara Education and Research Hospital, Ankara, Turkey
2 Department of Gastroenterology, Ankara Education and Research Hospital, Ankara, Turkey
3 Department of Surgery, Ankara Education and Research Hospital, Ankara, Turkey
4 Department of Biochemistry, Ankara Education and Research Hospital, Ankara, Turkey
5 Department of Gastroenterology, Ankara Dkap Education and Research Hospital, Ankara, Turkey
6 Department of Gastroenterology, Ankara Numune Hospital, Ankara, Turkey
7 Department of Rheumatology, Hacettepe University School of Medicine, Ankara, Turkey
Correspondence to:
Dr S Köklü, Karargahtepe mahallesi, Kumrulu sokak, 18/1 Keçiören, Ankara, Turkey; gskoklu{at}yahoo.com
Background: Adenosine deaminase (ADA) is found in most tissues including lymphoid cells and lymph nodes. It is a marker of T lymphocyte activation. The role of type 1 and type 2 T helper cells in appendicitis has been investigated experimentally. Serum ADA levels in acute appendicitis have not previously been studied.
Aim: To assess the serum levels of ADA in patients with acute appendicitis.
Methods: Serum levels of ADA were investigated in 30 cases with acute appendicitis (mean age 26 years; male/female 17/13) and 21 healthy controls (mean age 40 years; male/female 11/10). Levels of ADA were compared in patients with acute appendicitis and healthy controls. Correlation analysis between ADA and other inflammatory markers (C-reactive protein (CRP), high-sensitivity CRP, erythrocyte sedimentation rate and white blood cell count) was also performed.
Results: Mean (SD) serum ADA levels were significantly higher in those with acute appendicitis than in the control group (13.41 (3.56) U/l vs 9.39 (1.22) U/l; p<0.001). There was no correlation between ADA and the other inflammatory markers investigated.
Conclusions: Although serum levels of ADA do not correlate with other known inflammatory markers, its serum level is increased in acute appendicitis and it has a higher positive predictive value.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
