© 2004 BMJ Publishing Group Ltd, British Association for Accident & Emergency Medicine, & Faculty of Accident & Emergency Medicine
EDITORIAL
Anaphylaxis
Anaphylaxis gets the adrenaline going
Correspondence to:
Correspondence to:
A F T Brown
Department of Emergency Medicine, Royal Brisbane Hospital, Brisbane, QLD 4029, Australia; af.brown@uq.edu.au
Andrenaline and now atropine for anaphylactic shock
Keywords: anaphylaxis; anaphylactic shock; adrenaline; epinephrine; neurocardiogenic syncope
| The first 150 words of the full text of this article appear below. |
Anaphylaxis today still generates as much excitement, fear, rhetoric, and ripostes as it must have done for Charles Richet and Paul Portier at the turn of the 19th century. While they were guests on board Prince Albert of Monaco’s yacht in the Mediterranean, they reported on their experiments on dogs rechallenged with Physalia extracts, and first coined the phrase "anaphylaxis", literally meaning "against protection", when some dogs unexpectedly died. Since then, anaphylaxis has come to symbolise one of medicine’s great clinical bedside challenges, demanding rapid recognition without the benefit of an immediate laboratory test, and urgent management to avert a potentially fatal outcome usually in an otherwise healthy, young patient. Its evanescent nature has mitigated against the development of a solid scientific database to guide clinicians, and has generated as spiritedly polarised views on management as any therapeutic topic. No more so than when the use, dose, and delivery
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