COMMENTARY
Rectal infusion
Fluid replacement via the rectum for treatment of hypovolaemic shock in an animal model
1 Emergency Medicine Department, Manchester Royal Infirmary, Manchester, UK
2 Department of Intensive Care Medicine, Hope Hospital, Salford, UK
3 Exotic Species & Veterinary Services, Hornchurch, Essex, UK
Correspondence to:
Correspondence to:
Dr B A Foëx
Emergency Medicine Department, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK; bernard.foex@cmmc.nhs.uk
The rabbit may not be the ideal model to study fluid resuscitation by the rectal route
Accepted 19 October 2006
| The first 150 words of the full text of this article appear below. |
The study by Girisgin et al1 is an unusual one for the Emergency Medical Journal as it is an animal study. It raises some interesting issues:
- How valid is an animal model of haemorrhage?
- How valid is a rabbit model when investigating gut absorption of fluids?
- How valid is blood pressure as a biomarker of volume status?
- Why investigate the rectal route for fluid resuscitation?
To paraphrase HB Stoner,2 one of the fathers of trauma research in this country, a good animal model should fulfil certain criteria:
- It must be reproducible
- It must be measurable
- Its intensity must be controllable.
Models of haemorrhage may be classified into controlled and uncontrolled haemorrhages. Controlled haemorrhage may be either of the "Wiggers" type, in which blood is withdrawn until a specified hypotensive blood pressure is achieved,3,4 or of a fixed-volume type, in which a predetermined volume of blood is removed irrespective
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