Emergency casebook
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Serotonin Syndrome is an underreported and underecognised condition that occurs on administration of selective serotonin re-uptake inhibitors alone, or in combination with other medication known to increase levels of 5- Hydroxytryptamine. This case demonstrates the signs and symptoms associated with this condition and illustrates the importance of recognition of this syndrome in order to instigate appropriate treatment for the patient. The report illustrates a severe case of serotonin syndrome unusually resulting from the overdose of a single serotonergic agent, paroxetine. The patient developed the classic signs & symptoms which include changes in mental status, neuromuscular hyperactivity and autonomic instability within hours of ingestion which initially puzzled the clinicians involved. The incidence of this condition is unknown but is likely to be underreported because it is not recognized or is confused with neuroleptic malignant syndrome. This potentially life-threatening condition requires a heightened clinical awareness in order to recognise and treat the
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