BEST EVIDENCE TOPIC REPORTS
BET 1. SUBLINGUAL ADRENALINE TABLETS: HOW FEASIBLE IS THIS NOVEL APPROACH TO THE TREATMENT OF ACUTE ALLERGIC REACTIONS?
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Report by: Deepak Doshi, Specialist Registrar in Emergency Medicine
Search checked by: Bernard A Foëx, Consultant in Emergency Medicine and Critical Care Aesthetics
Institution: Manchester Royal Infirmary, Manchester, UK
A short-cut review was carried out to establish whether sublingual adrenaline tablets might be useful in the management of acute allergic reactions. Three animal studies and one case report were directly relevant to the question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are shown in table 1. The clinical bottom line is that sublingual adrenaline tablets may have a future in clinical practice but first we need clinical trials of their safety and efficacy.
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View this table: Table 1 Relevant papers
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In a [patient with an acute allergic reaction] does [a sublingual adrenaline tablet as compared to an intramuscular injection] work [better at reversing symptoms and preventing adverse effects
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