BEST EVIDENCE TOPIC REPORTS
BET 2. NEBULISED SALBUTAMOL OR NEBULISED ADRENALINE FOR WHEEZE IN ANAPHYLAXIS
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Report by: Deepak Doshi, Specialist Registrar in Emergency Medicine
Search checked by: Bernard A Foëx, Consultant in Emergency Medicine and Critical Care Aesthetics
Institution: Manchester Royal Infirmary, Manchester, UK
A short-cut review was carried out to establish whether nebulised salbutamol or adrenaline should be used to manage wheeze in anaphylaxis. No studies were found that addressed this clinical question. The clinical bottom line is that patients with anaphylaxis and breathing difficulties should be managed according to the latest Resuscitation Council guidelines and should be given intramuscular adrenaline in the first instance.
In [patients with anaphylaxis] is [nebulised salbutamol better than nebulised adrenaline] at [reducing wheeze]?
A 33-year-old school teacher arrives in the emergency department following a trip to the local botanical gardens. She has breathing difficulty, with extensive expiratory wheeze and a florid urticarial rash. She was given salbutamol by nebuliser in the ambulance. She continued to wheeze
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