ABSTRACTS FOR VENOUS THROMBOEMBOLISM, FREE PAPER SESSION
Abstracts for Venous Thromboembolism, Free Paper Session, Thursday 17 September 10.30–11.15, Pippard Lecture TheatreTHREAD space study: diagnosing venous thromboembolism using respiratory dead space and D-dimer
Salford Royal Hospital
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Introduction
Deep vein thrombosis (DVT) and pulmonary embolism (PE) investigation is costly and time consuming to hospital resources and patients. Patients can experience lengthy waits for invasive procedures. Our previous research suggested that combined dead space and D-dimer could safely exclude PE in patients with pleuritic chest pain. This study aimed to assess a non-invasive bedside rule-out strategy by measuring respiratory dead space combined with D-dimer in a more generalised population.
Method
This was a prospective diagnostic study set in Salford Royal Hospital, a large city centre hospital. During May–June 2009, any patient investigated for DVT or PE was approached. Exclusion criteria were lack of capacity or age <16 years. Dead space was calculated with the Bohr equation using end-tidal CO2 and mixed expired CO2 values (as recorded by CO2SMO+). All patients had D-dimer testing (IL-test). A
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