ABSTRACTS FOR VENOUS THROMBOEMBOLISM, FREE PAPER SESSION
Abstracts for Venous Thromboembolism, Free Paper Session, Thursday 17 September 10.30–11.15, Pippard Lecture TheatreGel point and fractal microstructure of incipient blood clots are significant new markers of haemostasis
Morriston Hospital
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Introduction
We have investigated the hypothesis that, in whole blood, the incipient clot formed at the gel point (GP) is characterised by a fractal microstructure1 2 and that this could be detected in healthy and anticoagulated blood. We compared the gel time (GT) required to form the incipient clot and the corresponding fractal dimension (df) against laboratory markers of haemostasis and thromboelastography.
Methods
Blood samples were taken from 52 healthy adults and 34 individuals whose blood had been anticoagulated with heparin over the therapeutic range.
Results
The incipient clot in normal blood is established as a sample-spanning network cluster at the GP.3 The value of df in whole healthy human blood is 1.74 (±0.07), which indicates a high degree of branching in the fibrin network at criticality and is commensurate with that reported to arise in other biological
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