ABSTRACTS FOR PAEDIATRIC TRAUMA, FREE PAPER SESSION
Abstracts for Paediatric Trauma, Free Paper Session, Thursday 17 September 17.15–18.15, Read Lecture TheatreIs therapeutic hypothermia of benefit in the management of severe paediatric traumatic brain injury? A review
West Middlesex Hospital
| The first 150 words of the full text of this article appear below. |
Objective
To identify whether hypothermia instituted as an adjuvant therapeutic modality offers benefit in the management of severe traumatic brain injury in children.
Data Sources
An electronic search of MEDLINE (OVID), EMBASE, the Cochrane library and a hand search of references was performed. The corresponding author(s) of identified studies were contacted for additional unpublished or ongoing clinical trials.
Study Selection
All randomised controlled trials of therapeutic hypothermia in children with traumatic brain injury were reviewed.
Data Synthesis
Four randomised controlled trials were identified; three had small numbers with the largest including 225 patients. All the studies reported lower intracranial pressure in those treated with hypothermia. Additionally, three studies reported that a good outcome was associated intracranial pressure <20 mm Hg in both normothermia and hypothermia groups. None of the trials demonstrated an overall benefit of hypothermia with respect to mortality and neurological outcome
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