Emerg Med J 18:236-241 doi:10.1136/emj.18.4.236
  • Review

Tricyclic antidepressant overdose: a review

  1. G W Kerr1,
  2. A C McGuffie2,
  3. S Wilkie2
  1. 1Accident and Emergency Department, Ayr Hospital, Dalmellington Road, Ayr, Scotland
  2. 2Accident and Emergency Department, Crosshouse Hospital, Kilmarnock
  1. Correspondence to: Dr Kerr (gary.kerr{at}
  • Accepted 26 September 2000


Overdoses of tricyclic antidepressants are among the commonest causes of drug poisoning seen in accident and emergency departments. This review discusses the pharmacokinetics, clinical presentation and treatment of tricyclic overdose.


  • Funding: none.

  • Conflicts of interest: none.

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