Table 2
| Author, date and country | Patient group | Study type (level of evidence) | Outcomes | Key results | Study weaknesses |
|---|---|---|---|---|---|
| Ruddy JM et al, 1972, Australia | 4 year old ingested about 1000 mg imipramine, episode of PEA 1.5 hours duration | Case report | Cardiac status | Improved with 1 mg boluses glucagon | Case report |
| Patient also received pyridostigmine, sodium bicarbonate, isoprenaline, digoxin, lignocaine and mannitol | |||||
| Sener EK et al, 1995, UK | 25 year old woman. Plasma toxicology - imipramine 3.0 mg/l, desipramine 0.18 mg/l, diazepam 2.9 mg/l, nordiazepam 2.2 mg/l, chlorpromazine 0.3 mg/l, temazepam 0.25 mg/l | Case report | Blood pressure | No response to 1 mg bolus glucagon. 40 mm Hg systolic rise after glucagons | Multiple drugs ingested in overdose |
| Patient also received sodium bicarbonate, phenytoin and isoprenaline and fluid resuscitation | |||||
| Cardiac rhythm | No response to 1 mg bolus glucagon. Broad complex reverted to sinus after 10 mg bolus | ||||
| Sensky PR and Olczak SA, 1999, UK | 36 year old OD-admission toxicology dothiepin 2.58 mg/l, desmethyldothiepin 0.51 mg/l, paracetamol 135 mg/l, diazepam 0.33 mg/l, nordiazepam 0.12 mg/l | Case report | Blood pressure | No response to 1 mg bolus glucagon. 30 mm Hg systolic rise after glucagons | Case report |
| Multiple drugs ingested in overdose | |||||
| Cardiac rhythm | No response to 1 mg bolus glucagon. Broad complex reverted to sinus after 10 mg bolus | Patient also received n-acetylcysteine, adrenaline, noradrenaline, ephedrine, dobutamine, and aminophylline with fluid restriction |
