Table 5
| Author, date and country | Patient group | Study type (level of evidence) | Outcomes | Key results | Study weaknesses |
|---|---|---|---|---|---|
| Vale JA, 1981, UK | 158 patients with paracetamol overedose. Mean age: 26 y. 1:2 M, F ratio | Prospective observational | Liver damage: | NSD | No randomisation |
| Methionine within 10 h (n=96) | 7% | Small study | |||
| High risk patients defined as paracetamol level: >300 mg/l at 4 h. | IV n-acetylcysteine within 10 h (n=62) | 2% | 2 of 7 vomited the first dose | ||
| In high risk patients methionine. within 10 h (n=43) | 14% | ||||
| In high risk patients IV n-acetylcysteine. within 10 h (n=33) | 3% | ||||
| Prescott LF, 1981, UK | 104 patients with paracetamol overdose. Mean age 33 y 1:1.5 M, F ratio | Prospective observational | Liver damage: | NSD | No randomisation |
| Methionine. Within 10 h, (n=42) 57% of them were high risk | 7% | Small study | |||
| High risk patients defined as paracetamol level: >300 mg/l at 4 h | IV n acetyl cysteine within 10 h (n=62) 33of 62 (53%) of them were high risk | 2% |
