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Core–peripheral temperature gradient as a diagnostic test in dyspnoea
  1. S F J Clarke1,
  2. R J Parris1,
  3. K Reynard2
  1. 1South Manchester University Hospital, Southmoor Road, Wythenshawe, Manchester, UK
  2. 2St James’s University Hospital, Beckett Street, Leeds, UK
  1. Correspondence to:
 Dr S Clarke
 Locum Consultant in Emergency Medicine, South Manchester University Hospital, Southmoor Road, Wythenshawe, Manchester, M23 9LT, UK; sfjclarkedoctors.org.uk

Abstract

Objectives: To evaluate whether the core–peripheral temperature gradient could be used to distinguish between cardiac and respiratory causes of dyspnoea.

Methods: In total, 50 patients were enrolled in the study, based on the following inclusion criteria: (a) a primary presenting complaint of dyspnoea; (b) age >40 years; (c) respiratory rate >20 breaths/min; (d) hypoxia. The tympanic temperature and the temperature of the nasal tip were recorded, and the patient’s discharge data and chest x ray results checked. Where there was discordance, arbitration was carried out by another researcher.

Results: Four patients were excluded, hence the final study sample was 46 patients. There was a statistically significant difference between the mean temperature gradients of the two study populations (p <0.001). A gradient of >8°C was able to rule in a cardiovascular cause (92% specificity) whereas one of <5°C could rule it out (100% sensitivity).

Conclusion: The test is safe, non-invasive and inexpensive. Although there were some limitations to the study, the test can still be commended as a useful adjunct to the emergency assessment of the acutely breathless patient.

  • Breathlessness
  • core peripheral temperature
  • dyspnoea
  • temperature gradient

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A patient presenting to an emergency department (ED) with dyspnoea is a common problem that requires rapid diagnosis and treatment, but may present a diagnostic dilemma. Dyspnoea may be the manifestation of a wide range of pathological conditions, most commonly lung or heart disease, that share similar risk factors and that often coexist. It may be difficult to obtain a history from a severely breathless patient, thus useful information such as other symptoms, previous episodes, and drug therapy may be unobtainable or missed. The breathless patient may have clinical features that do not easily differentiate the key causes.

The severity of illness is often such that treatment cannot be delayed pending the results of chest radiography or other investigations. This may result in treatment with any combination of bronchodilators, steroids, nitrates, diuretics, or antibiotics prior to a definitive diagnosis being made. This polypharmacy has the potential for adverse effects and adds to the cost of patient care.

Since the 1960s the measurement of changes in skin temperature and, more latterly, the core–peripheral temperature gradient, has been advocated as an indirect, non-invasive method of monitoring the treatment of shock;1,2,3,4,5,6,7,8,9,10 it has been used in the postoperative care of cardiothoracic surgical patients 11–14 and in neonatal intensive care medicine,15 and it has been advocated as an indication of haemodynamic dysfunction during cardiac exercise testing.16

Reduced peripheral perfusion is an early feature of symptomatic cardiac disease, as opposed to respiratory failure, in which it develops late in the pathological process. The aim of this study was to evaluate the ability of the core–peripheral temperature gradient in helping to distinguish between cardiac and respiratory causes of dyspnoea.

PATIENTS AND METHODS

The ED of South Manchester University Hospital sees approximately 65 000 new patients yearly, with shortness of breath being the primary presenting condition in approximately 5% of adult patients. The hospital receives tertiary referrals for both cardiology and respiratory medicine.

Ethics committee approval was granted for the study. Patients fulfilling the following inclusion criteria were invited to participate in the study: (a) a primary presenting complaint of dyspnoea; (b) age >40 years; (c) respiratory rate >20 breaths/min; (d) hypoxia, as measured by pulse oximetry (SpO2 <90% with the patient breathing room air, or <96% on supplemental oxygen). No other factors influenced the recruitment of patients.

The attending doctor recruited eligible patients who were given both written and verbal information regarding the study. An infrared thermometer (Genius First Temp; Tyco Health Care, Hampshire, UK) that could measure both tympanic and surface temperature was used to measure the tympanic membrane temperature and the nose tip temperature, the latter by holding the instrument just above the skin in "scan" mode. These measurements were made only once, as would happen in routine clinical practice, and were made early in the assessment of the patient as an extension of the routine measurement of observations and therefore before a clinical diagnosis was made. The actual temperature gradients were calculated at a later date and therefore did not influence diagnosis or management.

Each patient’s tympanic temperature and the highest reading from their nasal tip was recorded on a standardised form, along with their demographic details and specific inclusion criteria.

The "gold standard" diagnosis was obtained using both clinical and radiological criteria. Firstly, the medical records were searched for the discharge diagnosis; secondly, the initial chest x ray for each patient was reviewed by one of two consultant radiologists who reported the evidence for heart or pulmonary pathology on each film to provide a radiological diagnosis. If the discharge and x ray diagnoses concurred, then this was taken as the "gold standard"; if they disagreed, then the notes and x rays of this and any available previous admissions were scrutinised by one of the authors (KR) who arbitrated. All of these assessments were carried out by personnel blinded to the core–peripheral temperature gradient. In patients who subsequently died, the postmortem diagnosis was sought.

A list of temperature gradients for each diagnosis (cardiac or pulmonary) was constructed, and the mean, median, and range for each list was calculated; Student’s t test was performed to ascertain the significance of the difference between the two study populations. The ability of the temperature gradient to diagnose cardiovascular disease was assessed by calculating the specificities, sensitivities, and likelihood ratios of a range of different temperature gradients by constructing a series of 4×4 tables as previously described;17 a receiver operator characteristic (ROC) curve was derived from these results.

RESULTS

In total, 50 patients were entered in the study. These patients were recruited as a convenience sample, although patients were enrolled during both day and night. Four patients were excluded from the analysis: two did not fulfil the inclusion criteria and two were lost to follow up (no record could be found of one patient, while the other was transferred to another hospital and their chest x ray could not be located), thus the final study sample was 46 patients.

Overall, 21 patients (46%) had a diagnosis of cardiovascular disease (including two with angiographically confirmed pulmonary embolism), the remaining 26 (54%) having respiratory pathology. Table 1 contains the demographic characteristics and summary details of the temperature gradients of the two groups. There was a statistically significant difference between the mean temperature gradients of the two study populations (p <0.001). The sensitivities, specificities, and likelihood ratios for a range of values of temperature gradient are shown in table 2 and the ROC curve in fig 1.

Table 1

 Characteristics of the study subpopulations

Table 2

 Sensitivities, specificities, and likelihood ratios

DISCUSSION

Measuring the skin temperature provides an indirect, non-invasive assessment of the state of the peripheral circulation. This is influenced by both cardiac output and the tone of the arteriolar vessels, which are in turn affected by numerous interrelated factors such as blood volume, myocardial contractility, sympathetic nervous system stimulation, circulating vasoactive substances, and local homeostatic mechanisms.

Much of the published evidence on the temperature gradient has focussed on its clinical applications in shock. Studies have indicated that changes in peripheral temperature have prognostic2,5,6,8,12–14 and diagnostic4,11–14 value in hypovolaemic and cardiogenic shock, and can be used as a non-invasive guide to adequacy of fluid1,3,7,8,15 and even inotropic therapy.3,5 This study demonstrates that the patients with cardiovascular causes for their breathlessness have significantly different test results (p <0.001) from those with respiratory causes (table 2).

At ΔT ⩾8°C to diagnose a cardiovascular cause for breathlessness, the specificity was 92% (positive likelihood ratio 7.74). Using this level as a criterion for cardiac causes of breathlessness allows targeted treatment to be commenced while the results of further tests, including chest radiographs, are awaited. In this study, 33% of patients could be considered the "rule in" group–that is, a cardiac cause could be diagnosed. Sensitivity was maintained at 100% with ΔT ⩽5°C (negative likelihood ratio 0). Cardiac causes of breathlessness were ruled out by ΔT ⩽5°C; this is likely to be useful clinically. In this study, 39% of patients fell into this group.

The test was applied to unselected patients attending the ED. Using a ΔT ⩽5°C cut off to rule out a cardiac cause for the dyspnoea and a ΔT8°C cut off to rule in, almost three quarters of these patients could have their emergency treatment limited to appropriate agents while a chest x ray was performed and other information obtained.

A potential weakness of the study is the position of the sites of temperature measurement, which were chosen for their ease of use. All of the clinicians who enrolled patients to the study were trained in the use of the thermometer, which should have minimised variations in tympanic readings. However, temperature of the nasal tip could be influenced by the oxygen flow given to the patient, with higher flows having a greater cooling effect than lower flows (which may be given to patients with chronic obstructive airway disease). Although at the time of the study, the local ambulance service that brought all of the patients to the department had a policy of giving high flow oxygen therapy (15 l/min via a reservoir mask) to all breathless patients, this could be a potential confounding factor to future use. Further assessment is required in this patient group, and further research is planned to attempt to validate these results using the great toe as an alternative site for measurement of peripheral temperature.

What is already known on this topic

  • The core–peripheral temperature gradient has been used as a non-invasive assessment of haemodynamic status.

  • Clinical examination does not always readily distinguish between cardiac and respiratory causes of dyspnoea, and therefore appropriate treatment can be delayed.

What this paper adds

  • Measurement of the difference between tympanic and nasal tip temperatures can be used to distinguish between cardiac and respiratory causes of dyspnoea.

  • This study proposes a novel use for the measurement of the core–peripheral temperature gradient: a gradient of >8°C can be used to rule in a cardiovascular cause (92% specificity) whereas one of <5°C can rule it out (100% sensitivity).

The test is safe, non-invasive and inexpensive. We did not assess the effect on outcomes of applying this test result to directing patient treatment but the test can still be commended as a useful adjunct to the emergency assessment of the acutely breathless patient.

REFERENCES

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Footnotes

  • Competing interests: Tyco Healthcare provided a tympanic membrane thermometer and disposables for the duration of the study. No other funding was received.

  • We thank A Horrocks and R Sawyer for reviewing the chest radiographs of the patients in the study.

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