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Two cases of retroperitoneal haematoma caused by interaction between antibiotics and warfarin
  1. S Phillips,
  2. A Barr,
  3. E Wilson,
  4. T A Rockall,
  5. J F Stebbing
  1. Department of Surgery, Royal Surrey County Hospital, Egerton Road, Guildford, Surrey, UK
  1. Correspondence to:
 Dr S Phillips
 Department of Surgery, Royal Surrey County Hospital, Egerton Road, Guildford, Surrey GU2 7XX, UK; drsimonphillips{at}hotmail.com

Abstract

Several commonly prescribed antibiotics are known to interact with warfarin, increasing its anticoagulant effect by different mechanisms. Retroperitoneal bleeding with consequent haematoma is recognised as a complication of over-anticoagulation. Consequences, which are potentially fatal, include hypovolaemic shock and compression of retroperitoneal structures such as the ureter and inferior vena cava.

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Footnotes

  • Competing interests: there are no competing interests

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