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Early goal-directed therapy: a UK perspective
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- Published on: 29 April 2016
- Published on: 29 April 2016Tissue pHShow More
Dear Editor
"Although haemodynamic and oxygenation profiles were initially similar, non-survivors had substantially reduced [sublingual] microcirculatory changes and small-vessel perfusion"(1,2). Why? Because the interstitial pH was lower in non-survivors than survivors and so their relative need for blood flow was reduced by the up-regulation of oxidative phosphorylation presumably achieved by increasing the prot...
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