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Emerg Med J 2006;23:874-875 doi:10.1136/emj.2006.042176
  • Best evidence topic reports

Diagnosis of drug overdose by rapid reversal with naloxone

  1. Jenifer Barrie, Medical student,
  2. Gabby May, Clinical Fellow in Paediatric Emergency Medicine
  1. Manchester Medical School, Manchester, UK

      Report by Jenifer Barrie, Medical student 
 Search checked by Gabby May, Clinical Fellow in Paediatric Emergency Medicine 
 Manchester Medical School, Manchester, UK

      Abstract

      A short-cut review was carried out to establish whether naloxone may have an awakening effect in patients who have not taken opiates, thereby clouding its use as a diagnostic manoeuvre. The clinical bottom line is that opioid antagonists are able to reverse symptoms such as altered consciousness in patients who have not taken an overdose of opiates. It is unclear in which conditions …

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