Dolasetron overdose resulting in prolonged QTc interval and severe hypotension: a case report and literature review
- 1Department of Emergency Medicine, St Vincent’s Hospital, Darlinghurst, Sydney, New South Wales, Australia
- 2Department of Cardiology, Mayo Clinic, Rochester, Minnesota, USA
- 3Department of Intensive Care, Sutherland Hospital, Sydney, New South Wales, Australia
- Correspondence to: Dr M Rochford 4107, 90–98 King St, Randwick, Sydney, NSW 2031, Australia; mrochford1{at}hotmail.com
- Accepted 30 January 2007
Abstract
Dolasetron (Anzemet) overdose is uncommon, and, to our knowledge, this is the only case report of an intentional overdose. Dolasetron (dolasetron mesylate) is a selective 5-hydroxytryptamine 3 antagonist derived from pseudopelletierine, and is used in the prevention and treatment of nausea and vomiting. Transient and asymptomatic ECG changes, including QRS widening and PR and QTc prolongation, have been reported in therapeutic doses. The case of a 21-year-old woman who presented after an intentional overdose of 10×200 mg dolasetron tablets resulting in prolongation of the QTc interval and severe hypotension is reported here. Management of hypotension included intravenous fluid resuscitation and norepinephrine infusion with invasive monitoring in a high dependency unit. Sodium cardiac channel block contributes to cardiotoxicity observed in dolasetron overdose. Sodium bicarbonate was used in an attempt to reduce cardiac sodium channel block, although we observed no apparent benefit. As dolasetron becomes more commonly used in the outpatient setting, both doctors and patients need to be aware of the dangers of dolasetron in toxic doses. The pharmacology and toxicology of dolasetron are discussed.
Footnotes
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Funding: None.
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Competing interests: None.
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Informed consent has been obtained from the patient for publication of her details in this paper.
MR initiated the idea, reviewed the literature and wrote the paper. TJK initiated the idea, helped with the literature search and writing the paper, and edited the figures. AA initiated the idea and helped in the writing and revision of the paper.
