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BET 2. SHOULD ONDANSETRON BE USED AS THE FIRST-LINE ANTI-EMETIC IN PARACETAMOL OVERDOSE?

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Report by Emma Jenkinson, Foundation Year One

Checked by Nigel Langford, Consultant

Institution: City Hospital, Birmingham, UK

A review was carried out to establish whether evidence exists to support the use of ondansetron as the first-line anti-emetic in patients with paracetamol overdose. Four papers were found using the reported searches. Ondansetron appears to be an effective anti-emetic in this patient group. It is, however, more expensive than alternative anti-emetics, and there is insufficient evidence to support its use as a first-line agent.

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