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Emerg Med J 2008;25:165-166 doi:10.1136/emj.2007.056770
  • Best Evidence Topic reports

BET 2. COMBINATION THERAPY WITH H2 AND H1 ANTIHISTAMINES IN ACUTE, NON-COMPROMISING ALLERGIC REACTIONS

Report by TB Fogg, Clinical Fellow, D Semple, Senior House Officer in Emergency Medicine

Checked by Howard Simpson, Consultant in Emergency Medicine

Institution: North Hampshire Hospital, Basingstoke, UK

A short cut review was carried out to establish whether there was any benefit to using an H2 antihistamine in the management of an acute allergic reaction. Four clinical trials were found to answer the question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are presented in table 2. The clinical bottom line is that the combination of H1 and H2 antihistamines may accelerate …

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