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BET 3. TOXIC LEVELS OF TRICYCLIC DRUGS IN ACCIDENTAL OVERDOSE

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Report by Tom Bartram, Middle Grade in Emergency Medicine

Checked by Angela Coumbarides, Specialist Registrar in Emergency Medicine

Institution: Manchester Royal Infirmary, Manchester, UK

A short cut review was carried out to establish whether there are any published minimum toxic concentrations for tricyclic drugs taken in accidental overdose. A total of 578 papers met the search criteria. One was an evidence based guideline, which provided evidence to answer the question. The author, date and country of publication, study type, relevant outcomes, results and study weaknesses are presented in table 3. The clinical bottom line is that, for most tricyclic antidepressants, accidental overdose of …

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