Article Text

PDF
Serum adenosine deaminase levels in diagnosis of acute appendicitis
  1. Z A Öztürk1,
  2. S Köklü2,
  3. M F Erol3,
  4. F M Yılmaz4,
  5. Ö Başar5,
  6. O Yüksel6,
  7. G Yılmaz4,
  8. B Kısacık7,
  9. İ Yüksel5
  1. 1
    Department of Internal Medicine, Ankara Education and Research Hospital, Ankara, Turkey
  2. 2
    Department of Gastroenterology, Ankara Education and Research Hospital, Ankara, Turkey
  3. 3
    Department of Surgery, Ankara Education and Research Hospital, Ankara, Turkey
  4. 4
    Department of Biochemistry, Ankara Education and Research Hospital, Ankara, Turkey
  5. 5
    Department of Gastroenterology, Ankara Dışkapı Education and Research Hospital, Ankara, Turkey
  6. 6
    Department of Gastroenterology, Ankara Numune Hospital, Ankara, Turkey
  7. 7
    Department of Rheumatology, Hacettepe University School of Medicine, Ankara, Turkey
  1. Dr S Köklü, Karargahtepe mahallesi, Kumrulu sokak, 18/1 Keçiören, Ankara, Turkey; gskoklu{at}yahoo.com

Abstract

Background: Adenosine deaminase (ADA) is found in most tissues including lymphoid cells and lymph nodes. It is a marker of T lymphocyte activation. The role of type 1 and type 2 T helper cells in appendicitis has been investigated experimentally. Serum ADA levels in acute appendicitis have not previously been studied.

Aim: To assess the serum levels of ADA in patients with acute appendicitis.

Methods: Serum levels of ADA were investigated in 30 cases with acute appendicitis (mean age 26 years; male/female 17/13) and 21 healthy controls (mean age 40 years; male/female 11/10). Levels of ADA were compared in patients with acute appendicitis and healthy controls. Correlation analysis between ADA and other inflammatory markers (C-reactive protein (CRP), high-sensitivity CRP, erythrocyte sedimentation rate and white blood cell count) was also performed.

Results: Mean (SD) serum ADA levels were significantly higher in those with acute appendicitis than in the control group (13.41 (3.56) U/l vs 9.39 (1.22) U/l; p<0.001). There was no correlation between ADA and the other inflammatory markers investigated.

Conclusions: Although serum levels of ADA do not correlate with other known inflammatory markers, its serum level is increased in acute appendicitis and it has a higher positive predictive value.

Statistics from Altmetric.com

Footnotes

  • Competing interests: None.

  • Ethics approval: Ethics approval was obtained from the Ankara Training and Research Hospital for this study.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.