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BET 2. HEART FATTY ACID BINDING PROTEIN FOR RAPID DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION IN THE EMERGENCY DEPARTMENT

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Report by: Rick Body, Specialist Registrar in Emergency Medicine

Search checked by: Martin Newbury, Senior Clinical Fellow in Emergency Medicine

Institution: Hope Hospital, Salford, UK

A short-cut review was carried out to establish whether the measurement of plasma heart fatty acid binding protein at the time of presentation is of any help in the accurate early diagnosis of acute myocardial infarction (AMI). Six papers presented evidence addressing the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are shown in table 1. The clinical bottom line is that although heart fatty acid binding protein is a promising biomarker it cannot be used alone to rule out the diagnosis of AMI.

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Table 1 Relevant papers

THREE-PART QUESTION

In [patients who present to the emergency department with chest pain and have a suspected acute coronary syndrome] does [measurement of plasma heart fatty acid binding protein at the time of presentation] enable [accurate early diagnosis of acute myocardial infarction]?

CLINICAL SCENARIO

A 35-year-old man presents to the emergency department (ED) 15 minutes after having experienced 30 minutes …

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