Statistics from Altmetric.com
Use of Intralipid in tricyclic overdose
Report by: Dianne Tabone, ST4 Emergency Medicine
Search checked by: Lee Helliwell, SpR in Emergency Medicine
Institution: Royal Preston Hospital, Preston, UK
In [an adult with tricyclic anti-depressant poisoning] is [intravenous lipid mulsion / Intralipid / Liposyn II] benificial [in resistant hypotension and refractory dysrhythmias]?
A patient with tricyclic antidepressant overdose is treated in the Emergency Department. He is hypotensive and drowsy and has prolonged QTc on electrocardiogram. Blood gas shows metabolic acidosis. He is given intravenous fluids and sodium bicarbonate boluses until his pH becomes 7.6. However, he remains hypotensive. His rhythm then changes to VT. You remember that intravascular lipid emulsion (intralipid) has been used for overdoses of lipid-soluble drugs and you wonder whether it could be effective in this patient.
MEDLINE 1966 to Week 2 January 2010 …
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.