Article Text

PDF
Drug-induced movement disorders in children at paediatric emergency department: ‘dystonia’
  1. Oksan Derinoz1,
  2. Ayla Akca Caglar2
  1. 1Department of Pediatric Emergency, Gazi University Faculty of Medicine, Ankara, Turkey
  2. 2Department of Pediatrics, Gazi University Faculty of Medicine, Ankara, Turkey
  1. Correspondence to Dr Oksan Derinoz, Department of Pediatric Emergency, Gazi University Faculty of Medicine, Besevler, Ankara 06500, Turkey; oderinoz{at}gazi.edu.tr

Abstract

Aim To examine cases with drug-induced dystonic reactions (DIDRs), to identify the complaints of the application, to classify the drugs causing those dystonic reactions (DRs) and to determine the treatment options and protective measures to prevent DIDRs.

Method The authors retrospectively analysed 55 cases with DIDRs at paediatric emergency department (PED) in a 5-year period.

Results The mean age of the patients was 145.07±56.30 months, and of the 55 cases, 28 cases (50.9%) were boys. Antiemetics and antipsychotics were the most common causes of DIDRs. 35 (70%) patients developed DIDRs at therapeutic doses. Treatment side effect was the most common cause of the DIDRs (78.2%). The most common DIDRs were abnormal postures of the head and neck (56.6%). Laryngospasm was observed only in four cases (7.3%) that used either antipsychotics or psychostimulants. 51 (92.7%) children were treated with parenteral diphenhydramine successfully.

Conclusion Dystonia is a common side effect of certain drugs, even when therapeutic doses are administered. Although the most common DIDRs were abnormal postures of the head and neck, rare life-threatening conditions, may develop particularly due to use of antipsychotics. In treatment, diphenhydramine could effectively be used through parenteral way to eliminate the cholinergic effects of those drugs. However, the easiest and the safest way to prevent the development of DRs is to avoid unnecessary drug usage. In conclusion, physicians should be aware that antiemetic and antipsychotic drugs are associated with DRs in normal doses and that those drugs should be prescribed with a correct indication.

Statistics from Altmetric.com

Footnotes

  • Competing interests None.

  • Ethics approval Ethics approval was provided by the institutional ethics committee of Gazi University, Faculty of Medicine, Ankara, Turkey.

  • Provenance and peer review Not commissioned; externally peer reviewed.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.