Article Text

PDF
Changes to the cardiac biomarkers of non-elite athletes completing the 2009 London Marathon
  1. Polly Baker1,
  2. Sarah Louise Davies2,
  3. Joanne Larkin3,
  4. Daniel Moult4,
  5. Sally Benton5,
  6. Andrew Roberts6,
  7. Timothy Harris7
  1. 1Department of Sports Medicine and Rehabilitation, Defence Medical Rehabilitation Centre, Headley Court, Surrey, UK
  2. 2Department of Sports Medicine, Rheumatology and Rehabilitation, Royal National Orthopaedic Hospital, London, Stanmore, UK
  3. 3Institute of Sports, Exercise and Health, University College London, London, UK
  4. 4Department of Anaesthesia and Intensive Care Medicine, Kings College London, London, UK
  5. 5Department Clinical Biochemistry, Royal London Hospital, Barts and the London NHS Trust, London, UK
  6. 6Department of Research, Defence Medical Rehabilitation Centre, Headley Court, Surrey, UK
  7. 7Department of Emergency Medicine and Research, Queen Marys University London, London, UK
  1. Correspondence to Dr Polly Baker, Department of Sports Medicine and Rehabilitation, Defence Medical Rehabilitation Centre, Headley Court, Headley, Epsom, Surrey KT18 6JN, UK; pollybaker{at}cantab.net

Abstract

Introduction Many studies have demonstrated a rise in troponin and brain natriuretic peptide (BNP) levels following prolonged and/or strenuous exercise. Only one study looked at athletes who collapse and this showed no difference in cardiac biomarkers between those who collapsed and those who completed without requiring medical attention. We set out to describe and quantify the changes in troponin and BNP in three groups of non-elite runners at the 2009 London marathon: those with and without known structural heart disease (SHD) and those who collapsed on completion.

Methods The first group (recruited group, RG) was recruited at the prerace exhibition. This group had two subsets, runners with SHD and without (non-SHD). A second group was recruited from those who collapsed (collapsed group, CG). Blood was taken for troponin I (TnI), troponin T (TnT), high sensitivity TnT (HSTnT) and BNP.

Results Cardiac biomarker levels increased in all groups following the marathon. No statistically significant difference was seen between the SHD and non-SHD subgroups. When comparing the RG and CG the number and degree of rise was greater in those who collapsed. A trend for the degree of rise of HSTnT was demonstrated.

Discussion We identified runners with troponin levels that, in other circumstances, would raise concern for myocardial necrosis. However absence of adverse clinical sequelae would suggest this rise is physiological. The cause and clinical significance of the increased HSTnT levels seen in those that collapsed is yet to be fully elucidated.

  • clinical assessment
  • cardiac care

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.