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Recently the journal published a multicentre, randomised, controlled trial on the use of methoxyflurane for acute pain.1 Methoxyflurane is a volatile anaesthetic agent which, at low doses, has analgesic properties. It has been in widespread use as an analgesic in Australasia since as early as 1968 and there have been trials of its use in a variety of settings.2 In the UK and USA it does not currently have a license following safety concerns that it might precipitate renal failure.3
The trial concludes that methoxyflurane is an efficacious, safe and rapidly acting analgesic. The data presented do seem to support those assertions, although a trial of this size will not reliably detect rare events related to safety. Readers must now ask some interesting and important questions about …
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