Cardiovascular effects of tricyclic antidepressant drugs: Therapeutic usage, overdose, and management of complications
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Efficient degradation of imipramine by iron oxychloride-activated peroxymonosulfate process
2018, Journal of Hazardous MaterialsCitation Excerpt :Generally, the influence of initial pH in heterogeneous catalytic PMS system was usually related to the fractions of PMS species and the zeta potential of catalysts [19,23]. It should be noted that, the IMI mainly exists as unionized form when pH is less than 8 since the pKa of IMI is 9.4 [44]. The electrostatic effect between SO4− and IMI thus could be neglected.
Molecular determinants of Kv7.1/KCNE1 channel inhibition by amitriptyline
2018, Biochemical PharmacologyCitation Excerpt :AMIT has been associated with risks of cardiac arrhythmia and sudden death [10–12] since it causes prolongation of the QT interval [13,14] and can generate torsades de pointes ventricular arrhythmia in human hearts [10–12]. In fact, it is well documented that cardiovascular toxicity is the leading cause of death related with AMIT overdose [15–17]. Some of the underlying mechanisms of AMIT toxic effects have been previously reported.
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