RT Journal Article SR Electronic T1 Issues and challenges for research in major trauma JF Emergency Medicine Journal JO Emerg Med J FD BMJ Publishing Group Ltd and the British Association for Accident & Emergency Medicine SP emermed-2017-207082 DO 10.1136/emermed-2017-207082 A1 Sharon Ann Swain A1 Graham Stiff YR 2018 UL http://emj.bmj.com/content/early/2018/01/10/emermed-2017-207082.abstract AB The starting point for evidence-based guidelines is the systematic review and critical appraisal of the relevant literature. This review highlights the risk of bias identified while critically appraising the evidence to inform the National Institute of Health and Care Excellence guideline on the assessment and initial management of major trauma.