| Mackenzie SJ et al 1990 Scotland | 2 patients with RSE. Standard treatment unsuccesful | Case series | Observation of seizure activity | Propofol stopped seizure activity clinically and on EEG | Case series |
| | | | | |
| Campostrini R et al 1991 Italy | 4 patients on ICU with RSE | Case series | Observation of seizure activity | Propofol infusion stopped apparent seizure activity | Case series |
| | | | | |
| Borgeat A et al 1994 Switzerland | Adult OD patient. Propofol was given to suppress EEG activity | Case report | Observation of EEG activity | Propofol appeared to suppress EEG seizure activity | Case report |
| | | | | |
| Kuisma M and Roine RO 1995 Finland | 8 adult patients in prehospital care with RSE. All patients were intubated and ventilated. All received propofol boluses of 100–200 mg. | Case series | Success at terminating seizures | All patients stopped RSE with propofol | Case series. Not clear if patients intubated before or after propofol usage. This could be a result of the use of propofol. |
| | | | | |
| Harrison AM et al 1998 USA | 9/12 child with hereditary fructose intolerance in RSE | Case report | Observation | RSE stopped on infusion of 3 mg/kg propofol | Case report Rare underlying disorder |
| | | | | |
| Stecker MM et al 1998 USA | 16 Adult patients with RSE. All patients intubated. | Open trial | Time to seizure termination (elimination of EEG and clinical seizures) | Thiopentone 123 min vs propofol 2.6 min (p=0.002) | Open trial. Some of the propofol patients part of another trial. others identified retrospectively. |
| Thiopentone (8) v propofol (8) 1mg/kg over 5 min, repeated if needed. | | Success at terminating seizures | Thiopentone 82% v propofol 63% (NS) | Very small trial |