| Borron SW et al, 1999, France | 38 acute poisonings of which 11 patients had plasma ethylene glycol concentrations of 0.20 g/l or more. | Prospective observational | Death | 1/38 patients died | Simple case series-all patients received fomepizole, no controls |
| | | Serum creatinine | 0/7 patients who had a normal renal function at presentation had no further deterioration in serum creatinine | Details regarding patient demographics and outcomes inadequate |
| | | Side effects from fomepizole | 4/38 experienced | No account taken of confounding alcohol ingestion |
| Brent J et al, 1999, USA | 23 acute poisonings of which 19 met inclusion criteria including a plasma ethylene glycol concentration of >20 mg per decilitre | Prospective observational | Death | 1/19 patients died | Simple case series studying the metabolic progress of patients |
| | | Serum creatinine | 17/19 underwent haemodialysis as per study protocol, 3/19 had an increased serum creatinine at last study reading | All patients received fomepizole - no controls |
| | | Ethylene glycol metabolites | All patients demonstrated progressive reduction in blood glycolate concentration | Authors cannot conclude that fomepizole is safe and effective |
| | | Cranial neuropathies | 0/19 patients | |
| | | Side effects | 2 patients had seizures, 2 patients experienced headaches, 2 patients became bradycardic | |