USET phase 242 | | 59 | | UK 2000 U/lb bolus, 2000 U/lb/h over 12 hours | | 4 (7) | | 1 (1) | | 8 (14) | | Angiographic diagnosis, repeated at 24 h showing improved pulmonary flow in UK group but equal at day 5 |
| | 54 | | UK 2000 U/lb bolus, 2000 U/lb/h over 24 hours | | 5 (9) | | 4 (7) | | 10 (19) | | |
| | 54 | | SK 250 000 unit bolus, 100 000 U/h over 24 hours | | 5 (9) | | 2 (4) | | 6 (11) | | |
Goldhaber et al 198843 | | 23 | | UK 2000 U/lb bolus, 2000 U/lb/h | | 2 (8.7) | | 1 (4) | | 11 (48) | | Perfusion/haemodynamics better at 2 h in rTPA but equal by 24 h. Trend towards more haemorrhage UK |
| | 22 | | Rt-PA 100 mg over 2 hours | | 2 (8.7) | | 0 | | 4 (18) | | |
Meyer et al 199244 | | 29 | | UK 4400 U/lb bolus, 4400 U/lb/h over 24 hours | | 1 (3.4) | | 2 (6.9) | | 8 (28) | | 2 h pulmonary haemodynamics favour rTPA but equal at 12 h |
| | 34 | | Rt-PA 80–100 mg over 2 hours | | 3 (8.8) | | 2 (5.9) | | 7 (21) | | |
Goldhaber et al 199245 | | 46 | | UK 1 000 000 U over 10 mins, 2 000 000 U over 110 mins | | 1 (2) | | 3 (6.5) | | 6 (13) | | No difference at 2 h angiogram or 24 h perfusion scan |
| | 44 | | Rt-PA 100 mg over 2 hours | | 2 (4.5) | | 0 | | 9 (20) | | |
Meneveau et al 199746 | | 25 | | SK 250000 bolus, 1 000 000 U/h over 12 hours | | 1 (4) | | 2 (8) | | 3 (12) | | 2 h pulmonary haemodynamics favour rTPA but no difference by 12 h |
| | 25 | | Rt-PA 100 mg over 2 hours | | 1 (4) | | 0 | | 4 (16) | | |
Meneveau et al 199847 | | 43 | | SK 1 500 000 U 2 hours | | 0 | | 1 (2.3) | | 3 (7.0) | | Identical haemodynamics at 2 h and identical day 2 perfusion scan |
| | 23 | | Rt-PA | | 0 | | 2 (8.7) | | 5 (21.7) | | |