Baseline characteristics of each non-invasive ventilation (NIV) indication group
| COPD | CPE + COPD | Pneumonia + COPD | Hypercapnic pneumonia +COPD | Ob-hypoven | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| CPEtotal | Hypercapnic | Non-hypercapnic | Pneumoniatotal | Hypercapnic | Non-hypercapnic | ||||||
| APACHE, Acute Physiology and Chronic Health Evaluation; CPE, cardiogenic pulmonary oedema; COPD, chronic obstructive pulmonary disease; F/M, female/male; ob-hypoven, obesity-hypoventilation decompensation. | |||||||||||
| *Trials with available arterial blood gas data: CPE 63/70; pneumonia 23/27; pneumonia + COPD 20/21. | |||||||||||
| †Mean ± standard deviation. | |||||||||||
| ‡Median, interquartile range (available data/number trials). | |||||||||||
| Number trials (number patients) | 70* (69) | 45 (44) | 18 (18) | 27* (26) | 12 (12) | 11 (11) | 39 (37) | 11 | 21* (20) | 18 (17) | 6 (6) |
| Age† | 76.4±12.5 | 77.3±12 | 76±10.7 | 64.9±14.9 | 66±13.7 | 62.3±16.8 | 71.3±8.1 | 83.8±6.4 | 74.6±9.9 | 73.9±10.1 | 58.1±5.4 |
| F/M | 44/25 | 30/14 | 10/8 | 10/16 | 4/8 | 5/6 | 15/22 | 7/4 | 7/13 | 6/11 | 3/3 |
| APACHE II† | 18.3±5.8 (66/70) | 18.5±5 (45/45) | 18.7±6.9 (16/18) | 18.6±5.1 (27/27) | 20.8±4.4 (12/12) | 17.7±5.4 (11/11) | 19±5.3 (38/39) | 19.4±6.5 (11/11) | 20.9±4.5 (21/21) | 21.1±4.8 (18/18) | 13.5±5.8 (6/6) |
| pH‡ | 7.27 | 7.24 | 7.34 | 7.37 | 7.31 | 7.44 | 7.26 | 7.24 | 7.29 | 7.27 | 7.26 |
| 7.19–7.31 | 7.16–7.29 | 7.29–7.41 | 7.3–7.42 | 7.16–7.36 | 7.39–7.47 | 7.21–7.3 | 7.19–7.28 | 7.22–7.34 | 7.21–7.33 | 7.22–7.3 | |
| (63/70) | (45/45) | (18/18) | (23/27) | (12/12) | (11/11) | (38/39) | (11/11) | (20/21) | (18/18) | (6/6) | |
| PaCO2‡ | 51 | 55 | 37.2 | 45 | 59.5 | 37 | 75.6 | 77 | 71 | 72.5 | 70.9 |
| 42.6–61.1 | 49–67 | 30.5–40.7 | 37.6–59.5 | 53.7–65 | 34.1–41 | 70.8–86.3 | 65–78.5 | 60.7–93 | 64.7–97 | 68.4–72.7 | |
| (63/70) | (45/45) | (18/18) | (23/27) | (12/12) | (11/11) | (39/39) | (11/11) | (20/21) | (18/18) | (6/6) | |
| PaO2‡ | 56 | 56 | 62.5 | 54 | 49.5 | 60 | 61 | 65 | 52.1 | 50.3 | 64.5 |
| 46–71.2 | 44.7–65.8 | 47.2–74.4 | 47.6–63 | 47–54.2 | 52.1–67 | 47–73 | 43.7–77.5 | 46–72.5 | 39.5–69 | 55.5–72.9 | |
| (62/70) | (44/45) | (18/18) | (23/27) | (12/12) | (11/11) | (37/39) | (11/11) | (20/21) | (18/18) | (6/6) | |
| PaO2/FiO2‡ | 185 | 165.5 | 223 | 142 | 175.5 | 105.5 | 184 | 191 | 161 | 197.5 | 252 |
| 134–242.2 | 129–231.5 | 204.2–244 | 91.5–196.7 | 111.7–237.7 | 86–173 | 154.5–213.5 | 116.5–257.2 | 144–240 | 146.2–243.7 | 218.5–295 | |
| (32/70) | (24/45) | (9/18) | (12/27) | (6/12) | (6/11) | (15/39) | (6/11) | (9/21) | (8/18) | (3/6) | |