Table 1

Author, date and countryPatient groupStudy type (level of evidence)OutcomesKey resultsStudy weaknesses
UK National External Quality Assessment Scheme for Immunochemistry Working Group, 2003, UK Review of current recommendations for clinical biochemists in the UKReview articleTime for formation of bilirubin in CSF.Selection of bilirubin as key determinantThis occurs 9–15 hours after a bleed. Bilirubin is the only product of red cell lysis that occurs solely in vivoNot systematic review. Basic data on which recommendation not given.