Table 4

 Emergency Department Trials

PaperN/ TypeGroupInterventionOutcomeComments
CVC, central venous cathetorisation; ED, emergency department; FV, femoral vein; IJ, internal jugular vein; RCT, randomised controlled trial; SC, subclavian vein.
Hilty et al2 199720 patients 40 CVC attempts RCTFemoral Vein CVC insertion in ED patients in cardiac arrest, by ResidentsTime to cannulationNo power calculation
Ultrasound121±60 secondsNo blinding
Landmark124.2±69 (p = 0.001)Small sample size
Number of attempts
Ultrasound2.3±3
Landmark5±5 (p = 0.0057)
Arterial puncture rate
Ultrasound0/20
Landmark4/20 (p = 0.025)
Success rate
Ultrasound90%
Landmark65% (p = 0.058)
Miller et al21 2002122 RCTED adult patients requiring CVC (IJ, SC & FV routes)Time to insertion (skin to blood)Different approaches (i.e. IJ, SC, FV) used in each group without pairing)
Ultrasound115±184 secondsNo blinding
Landmark512±698 (p<0.0001)
Number of attempts
Ultrasound1.55±1
Landmark3.54±2.68 (p<0.0001)
Complication rate
Ultrasound14%
Landmark12% (p = 0.71,NS)
Hrics et al22 199840 Descriptive study/Case seriesIJ CVC placement in ED patientsSuccess rateExempt from ethical approval
Realtime ultrasound7/8Variable ultrasound technique
Ultrasound marking site17/24No statistical analysis
Landmark5/8No randomisation or controls.