Hilty et al2 1997 | 20 patients 40 CVC attempts RCT | Femoral Vein CVC insertion in ED patients in cardiac arrest, by Residents | | Time to cannulation | No power calculation |
| | | Ultrasound | 121±60 seconds | No blinding |
| | | Landmark | 124.2±69 (p = 0.001) | Small sample size |
| | | | Number of attempts | |
| | | Ultrasound | 2.3±3 | |
| | | Landmark | 5±5 (p = 0.0057) | |
| | | | Arterial puncture rate | |
| | | Ultrasound | 0/20 | |
| | | Landmark | 4/20 (p = 0.025) | |
| | | | Success rate | |
| | | Ultrasound | 90% | |
| | | Landmark | 65% (p = 0.058) | |
Miller et al21 2002 | 122 RCT | ED adult patients requiring CVC (IJ, SC & FV routes) | | Time to insertion (skin to blood) | Different approaches (i.e. IJ, SC, FV) used in each group without pairing) |
| | | Ultrasound | 115±184 seconds | No blinding |
| | | Landmark | 512±698 (p<0.0001) | |
| | | | Number of attempts | |
| | | Ultrasound | 1.55±1 | |
| | | Landmark | 3.54±2.68 (p<0.0001) | |
| | | | Complication rate | |
| | | Ultrasound | 14% | |
| | | Landmark | 12% (p = 0.71,NS) | |
Hrics et al22 1998 | 40 Descriptive study/Case series | IJ CVC placement in ED patients | | Success rate | Exempt from ethical approval |
| | | Realtime ultrasound | 7/8 | Variable ultrasound technique |
| | | Ultrasound marking site | 17/24 | No statistical analysis |
| | | Landmark | 5/8 | No randomisation or controls. |