Table 4 Treatment regimens and co-interventions used in studies of nebulised magnesium sulphate
StudyMagnesium regimensTotal amount magnesium usedControl regimenBronchodilator regimenCo-interventions
Aggarwal1 ml MgSO4 (500 mg) (3 doses, 20 min apart) with β-agonist1500 mg (3×500 mg)1.5 ml distilled water7.5 ml normal salineSalbutamol 1 mlIV hydrocortisone + salbutamolDiscretion physician
Drobina125 mg MgSO4 0.25 ml of 50% solution (3 doses, 20 min apart) with β-agonist375 mg (3×125 mg)0.25 ml saline solution5 mg/ml albuterol + 2.5 ml ipratropium bromide50 mg oral prednisolone
KokturkIso-osmolar MgSO4 (6.3%, 145 mg/dose) (20 min intervals) with β-agonist1015 mg (7×145 mg)2.5 ml isotonic saline solution2.5 mg salbutamol1 mg/kg MP IV
Mahajan2.5 ml isotonic MgSO4 (6.3%) solution) single dose with β-agonist2.5 ml saline solutionAlbuterol 2.5 mg (0.5 ml)2 mg/kg prednisolone
Hughes2.5 ml isotonic MgSO4 (151 mg/dose) (3 doses at 30 min intervals) with β-agonist453 mg (3×151 mg)2.5 ml isotonic saline solution2.5 mg salbutamol100 mg hydrocortisone IV
BessmertnyMgSO4 384 mg (64 mg/ml) in 6 ml sterile water (3 doses at 20 min intervals) after β-agonist1152 mg (3×384 mg)6 ml saline solutionAlbuterol 2.5 mg/3 ml2 mg/kg hydrocortisone IV 6 hourly
Nannini3 ml isotonic MgSO4 (7.5 g/100 ml) single dose with β-agonist225 mg3 ml saline solutionSalbutamolNone stated
Mangat3 ml (95 mg) MgSO4 (4 doses, 20 min apart)380 mg (4×95 mg)3 ml salbutamol (2.5 mg)Part of control regimen100 mg hydrocortisone IV
Meral2 ml MgSO4 (280 mmol/l)2.5 mg/2.5 ml salbutamolPart of control regimenTheophylline
  • IV, intravenous; MP, methylprednisolone.