Table 2 Characteristics of ED patients receiving N2O for PSA (n  =  124)
n (%)
Age, years
    Mean, range8.1 (1.3–17.9)
    Median, IQR8.3 (4.9–11.0)
Sex
    Male80 (64.5)
ASA status§
    1 and 2118 (95.9)
    35 (4.1)
Percentage of N2O*
    70100 (80.6)
    606 (4.8)
    5018 (14.5)
Adjunctive agents†
    N2O alone109 (87.9)
    Codeine15 (12.1)
Primary procedures
    Laceration repair37 (29.8)
    Fracture reduction31 (25)
    Intravenous line insertion15 (12.1)
    Plaster/backslab15 (12.1)
    Relocation joint8 (6.4)
    Removal of foreign body7 (5.6)
    Removal of plaster, suture3 (2.4)
    Abscess drainage3 (2.4)
    Wound debridement1 (0.8)
    Joint aspiration1 (0.8)
    Other3 (2.4)
Sedation depth‡§
    01 (0.8)
    21 (0.8)
    36 (4.9)
    452 (42.3)
    558 (47.1)
    65 (4.1)
Adverse events
    None103 (83.1)
    Vomiting7 (5.6)
    Dizziness5 (4.0)
    Nausea4 (3.2)
    Agitation/hallucination2 (1.6)
    Other3 (2.4)
  • *Highest nitrous oxide (N2O) concentration administered.

  • †Adjunctive agents: codeine (alone or in combination with paracetamol) if given within 2 h before sedation.

  • ‡Sedation depth (see Methods).

  • ASA, American Society of Anesthesiologists; ED, emergency department; PSA, procedural sedation and analgesia.

  • §One missing.