Diagnostic performance of hs-TnT (at each cut-off) and cTnT in the cohort study and subsequent audit in clinical practice
| Assay and cut-off | Sensitivity | Specificity | PPV | NPV | LR+ | LR− |
| cTnT (cohort study) | 70.7 (59.7 to 80.3) | 92.8 (89.8 to 95.2) | 67.4 (56.5 to 77.2) | 93.8 (90.0 to 96.0) | 9.88 (6.73 to 14.49) | 0.32 (0.22 to 0.44) |
| hs-TnT (14 ng/l, cohort study) | 93.9 (86.3 to 98.0) | 77.8 (73.3 to 81.8) | 47.0 (39.1 to 54.9) | 98.4 (96.3 to 99.5) | 4.22 (3.48 to 5.12) | 0.08 (0.03 to 0.18) |
| hs-TnT (3 ng/l, cohort study) | 98.8 (93.4 to 100.0) | 30.7 (26.2 to 35.5) | 23.0 (18.7 to 27.8) | 99.2 (95.5 to 100.0) | 1.43 (1.33 to 1.53) | 0.04 (0.01 to 0.28) |
| hs-TnT (14 ng/l, audit) | 92.8 (90.4 to 94.7) | 97.2 (94.7 to 98.7) | 98.4 (97.0 to 99.3) | 87.9 (84.0 to 91.1) | 33.1 (17.4 to 63.0) | 0.07 (0.06 to 0.10) |
| hs-TnT (3 ng/l, audit) | 99.8 (99.1 to 100.0) | 49.5 (43.9 to 55.1) | 78.5 (75.4 to 81.4) | 99.4 (96.6 to 100.0) | 1.98 (1.77 to 2.20) | 0.00 (0.00 to 0.02) |
95% CIs in parentheses. 14 ng/l is the 99th percentile of the hs-TnT assay.
LR−, negative likelihood ratio; LR+, positive likelihood ratio; NPV, negative predictive value; PPV, positive predictive value.