Analysis of visual analogue scale (VAS) pain intensity score (intention-to-treat population): adjusted change from baseline
| Methoxyflurane (N=149) | Placebo (N=149) | Estimated treatment effect (95% CI) | p Value | |
|---|---|---|---|---|
| Adjusted* change from baseline (mm) | ||||
| Overall | −30.2 | −15.2 | −15.1 (−19.2 to −11.0) | <0.0001 |
| 5 min | −23.1 | −11.3 | −11.8 (−15.6 to −8.0) | |
| 10 min | −28.9 | −14.8 | −14.1 (−18.4 to −9.8) | |
| 15 min | −34.0 | −15.5 | −18.5 (−23.4 to −13.5) | |
| 20 min | −35.0 | −19.0 | −16 (−21.3 to −10.7) | |
| Time by treatment interaction | 0.0019 | |||
Pain scores recorded after the start of the planned emergency department procedure were excluded from the analysis. Pain scores taken after initiation of rescue medication were included in the analysis.
*Least squares mean has been adjusted for baseline pain score and age group (adolescent/adult).
N, number of patients.