Results of an interrupted time-series analysis comparing preintervention and postintervention drug use trends for selected antibacterial drug classes in medical emergency patients (n=46 preintervention and 24 postintervention monthly drug use density values expressed in RDD per 100 patient days)
| 1/2GC | 3GC | CEPH | Carbapenems | Aminopen/BLI | BSP | Fluorquinolones | PEN | Total | |
|---|---|---|---|---|---|---|---|---|---|
| Baseline trend | 0.0509 (−0.0496 to 0.151) | −0.218 (−0.448 to 0.0123) | −0.174 (−0.397 to 0.0492) | 0.0447 (−0.00845 to 0.0979) | 0.0107 (−0.0324 to 0.0538) | 0.0393 (−0.0500 to 0.129) | −0.0512 (−0.254 to 0.151) | 0.0559 (−0.0400 to 0.152) | −0.173 (−0.641 to 0.296) |
| Postintervention level change | 5.209* (0.131 to 10.29) | −15.19† (−24.08 to −6.311) | −9.827* (−18.72 to −0.931) | −3.445† (−5.473 to −1.417) | 6.619*** (4.169 to 9.069) | −5.179† (−8.506 to −1.852) | −3.695 (−11.72 to 4.333) | 1.904 (−2.028 to 5.837) | −19.76 (−39.99 to 0.466) |
| Constant | 2.339 (−0.446 to 5.124) | 39.61*** (32.87 to 46.35) | 42.03*** (35.72 to 48.35) | 2.909*** (1.407 to 4.412) | 0.630 (−0.217 to 1.478) | 15.03*** (12.33 to 17.72) | 20.53*** (15.13 to 25.93) | 16.69*** (14.00 to 19.38) | 115.2*** (103.0 to 127.5) |
| N | 70 | 70 | 70 | 70 | 70 | 70 | 70 | 70 | 70 |
95% CIs are shown in brackets; *p<0.05, †p<0.01, ***p<0.001.
GC, generation of cephalosporins; 3GC; third-generation cephalosporins; RDD, recommended daily doses.