Diagnostic characteristics of S100B in children aged <2 years, children aged 2–16 years and all children (<16 years)
| S100B | Children <2 years | Children 2–16 years | All children <16 years |
|---|---|---|---|
| n total (n with ICI) | 9 (2) | 64 (18) | 73 (20) |
| Area under the curve | 0.57 (0.00–1.00) | 0.77 (0.65–0.89) | 0.73 (0.60–0.86) |
| Sensitivity (95% CI)* | 50.0% (5% to 97%) | 100.0% (81% to 100%) | 95.0% (77% to 100%) |
| Specificity (95% CI)* | 14.3% (1% to 28%) | 37.0% (30% to 37%) | 34.0% (27% to 36%) |
| LR+ (95% CI)* | 0.58 (0.05 to 1.35) | 1.59 (1.16 to 1.59) | 1.44 (1.05 to 1.55) |
| LR− (95% CI)* | 3.50 (0.10 to 74.19) | 0.00 (0.00 to 0.63) | 0.15 (0.01 to 0.84) |
| S100B value, mean(SD) | 0.40 (0.35) | 0.54 (0.86) | 0.52 (0.81) |
| Time trauma to venous puncture (min), mean (SD) | 182.1 (91.3) | 168.2 (91.3) | 169.9 (90.8) |
*Cut-off value 0.14 µg/L.
ICI, intracranial injury; LR, likelihood ratio.