Reasons for not being thrombolysed (n=2019)
| Reason: time | ||
| Too late intravenous | 51 | 2.5% |
| Too late intravenous and no indication intra-arterial | 203 | 10.1% |
| Too late intravenous and intra-arterial | 418 | 20.7% |
| Unknown onset* | 667 | 33.0% |
| Total | 1339 | 66.3% |
| Reason: severity | ||
| Too mild† | 924 | 45.8% |
| Too severe‡ | 25 | 1.2% |
| Rapid improvement to below threshold | 18 | 0.9% |
| Total | 967 | 47.9% |
| Reason: age | ||
| >80 years till 2006§ | 285 | 14.1% |
| Reason: imaging | ||
| Too large infarct¶ | 32 | 1.6% |
| Too little penumbra | 12 | 0.6% |
| Too large infarct and too little penumbra | 7 | 0.3% |
| Large subacute infarct on imaging** | 18 | 0.9% |
| Other/intracranial haemorrhage | 23 | 1.1% |
| Total | 92 | 4.6% |
| Reason: high bleeding risk | ||
| INR elevated†† | 174 | 8.6% |
| Thrombocytopenia‡‡ | 6 | 0.3% |
| Recent intervention | 19 | 0.9% |
| Previous intracranial haemorrhage | 17 | 0.8% |
| Intracranial vascular malformation | 14 | 0.7% |
| Full dose heparin or LMWH | 20 | 1.0% |
| Other bleeding risk | 24 | 1.2% |
| Total | 274 | 13.6% |
| Reason: other | ||
| No good reason according to hospital recommendations (thrombolysis missed) | 57 | 2.8% |
| Recent stroke§§ | 51 | 2.5% |
| Stroke uncertain | 58 | 2.9% |
| Epileptic seizure | 13 | 0.6% |
| Comorbidity/dependency | 85 | 4.2% |
| Total | 290 | 14.4% |
*>60 min uncertainty and too late for thrombolysis.
†NIHSS <6 until September 2006, NIHSS <4 from October 2006 without isolated hemianopia or aphasia thereafter.
‡NIHSS>25 till September 2006, no limit thereafter.
§Since October 2006: >80 and significant comorbidity or dependency.
¶Non-contrast image or perfusion image.
**Defined as a poorly demarcated, hypodense territorial lesion with mild local swelling or absence of the usual atrophy of chronic stroke lesions.
††>1.2 before October 2006 and >1.5 thereafter.
‡‡<100 000/mm3.
§§Clinically or radiologically <3 months.
INR, international normalised ratio; LMWH, low molecular weight heparin; NIHSS, National Institute of Health Stroke Scale score.