Demographic and baseline characteristics
| Variables | Overall cohort (n=20 836) | No sepsis (n=20 035) | Sepsis* (n=581) | Severe† sepsis (n=194) | Sepsis with circulation dysfunction (n=26) | p Value |
|---|---|---|---|---|---|---|
| Demographics | ||||||
| Age, years±SD (95% CI) | 49±20 (49 to 49) | 49±20 (49 to 49) | 47±19 (51 to 53) | 65±15 (63 to 67) | 67±18 (60 to 74) | <0.001 |
| Men, n (%) (95% CI) | 10.795 (52%) (51 to 52) | 10.339 (52%) (51 to 52) | 327 (56%) (53 to 60) | 112 (58%) (52 to 63) | 17 (65%) (49 to 79) | <0.001 |
| Vital signs | ||||||
| Temperature (°C) (95% CI) | 36.5±0.7 (36.5 to 36.5) (n=19 848) | 36.4±0.6 (36.4 to 36.4) (n=18 683) | 37.8±1.4 (37.7 to 37.9) (n=579) | 37.4±1.4 (37.2 to 37.6) (n=193) | 37.5±1.6 (36.9 to 38.1) (n=26) | <0.001 |
| HR (bpm) | 84±17 (83.3 to 83.7) (n=19 759) | 83±17 (82 to 83) (n=18 958) | 104±16 (103 to 106) (n=581) | 106±20 (103 to 109) (n=194) | 114±18 (107 to 121) (n=26) | <0.001 |
| Systolic BP (mm Hg) | 139±22 (139 to 139) (n=19 759) | 139±22 (139 to 139) (n=18 814) | 138±24 (136 to 139) (n=580) | 139±25 (135 to 142) (n=193) | 83±7 (80 to 86) (n=26) | <0.001 |
| RR (breaths per minute) | 16±2 (16 to 16) (n=19 919) | 16±2 (16 to 16) (n=19 118) | 19±4 (18 to 19) (n=579) | 20±7 (19 to 21) (n=193) | 20±10 (16 to 24) (n=25) | <0.001 |
| Oxygen saturation (%) | 98±4 (98 to 98) (n=19 715) | 98±4 (98 to 98) (n=18 914) | 99±4 (99 to 99) (n=579) | 92±10 (90 to 93) (n=191) | 93±7 (90 to 96) (n=26) | <0.001 |
| Laboratory parameters | ||||||
| Base deficit (mmol/L) | 1.0±3.9 (0.9 to 1.1) (n=6275) | 1.0±3.9 (0.9 to 1.1) (n=5474) | 1.2±4.1 (0.9 to 1.6) (n=233) | −0.5±5.4 (−1.3 to 0.3) (n=161) | −2.1±6.1 (−4.6 to 0.4) (n=19) | 0.026 |
| Lactate (mmol/L) | 1.9±1.5 (1.8 to 1.9) (n=6298) | 1.9±1.5 (1.9 to 1.9) (n=5497) | 2.1±1.6 (2.0 to 2.2) (n=237) | 2.8±2.0 (2.5 to 3.1) (n=161) | 2.9±1.9 (2.1 to 3.7) (n=19) | <0.001 |
| Leucocytes(g/L) | 9.2±4.2 (9.1 to 9.3) (n=11 270) | 9.2±4.2 (9.1 to 9.3) (n=10 469) | 12.5±5.8 (12.0 to 12.9) (n=448) | 13.2±10.5 (11.8 to 14.7) (n=193) | 13.7±8.6 (10.2 to 17.2) (n=25) | <0.001 |
| Thrombocytes (g/L) | 238.1±83.4 (236.6 to 239.9) (n=11 179) | 238.3±82.4 (236.7 to 239.9) (n=10 378) | 242.2±94.1 (234.5 to 249.8) (n=445) | 219.5±139.7 (199.7 to 239.3) (n=190) | 162.7±105.7 (120.1 to 205.3) (n=23) | 0.016 |
| Creatine (mg/dL) | 1.1±1.1 (1.1 to 1.1) (n=11 269) | 1.1±1.1 (1.1 to 1.1) (n=10 468) | 1.8±1.7 (1.7 to 1.9) (n=448) | 1.8±1.6 (1.5 to 2.0) (n=193) | 2.0±2.3 (1.1 to 2.9) (n=25) | <0.001 |
A p value <0.001 indicates statistical significance between the groups.
*Sepsis: not severe/no circulation dysfunction.
†Severe sepsis without circulation dysfunction.