Table 3

Diagnostic accuracy of MACS and T-MACS

Sensitivity, n 
(95% CI)
Specificity, n 
(95% CI)
PPV, n 
(95% CI)
NPV, n 
(95% CI)
AMI
MACS rule very low risk 99.1%
(95.2% to 100%)
11.7%
(9.9% to 13.7%)
10.2%
(8.5% to 12.1%)
99.2
(95.9% to 100%)
MACS rule high risk49.1%
(39.6% to 58.7%)
97.6%
(96.5% to 98.4%)
67.5%
(56.3% to 77.4%)
95%
(93.6% to 96.2%)
T-MACS very low risk 99.1%
(95.2% to 100%)
21.7%
(19.3% to 24.2%)
11.3%
(9.4% to 13.5%)
99.6%
(97.8% to 100%)
T-MACS high risk43.0%
(33.7% to 52.6%)
98.4%
(97.5% to 99.1%)
73.1%
(60.9% to 83.2%)
94.5
(93.0% to 95.7%)
MACE
MACS rule very low risk 98.2%
(94.7% to 99.6%)
12.0%
(10.1% to 14.1%)
14.4%
(12.4% to 16.6%)
97.7%
(93.5% to 99.5%)
MACS rule high risk35.6%
(28.3% to 43.4%)
97.7%
(96.6% to 98.5%)
69.9%
(58.8% to 79.5%)
91%
(89.2% to 92.5%)
T-MACS very low risk 96.3%
(92.2% to 98.6%)
22.2%
(19.8% to 24.8%)
15.7%
(13.5% to 18.1%)
97.6%
(94.8% to 99.1%)
T-MACS high risk31.3%
(24.3% to 39.0%)
98.5%
(97.6% to 99.2%)
76.1%
(64.1% to 85.7%)
90.5%
(88.7% to 92.1%)
  • AMI, acute myocardial infarction; MACE, major adverse cardiac event; MACS, Manchester Acute Coronary Syndrome; T-MACS, Troponin-only Manchester Acute Coronary Syndrome. Bolded values represent the most relevant statistic for each category.