Experimental studyElectrophysiologic effects of imipramine and doxepin on normal and depressed cardiac Purkinje fibers☆
References (35)
- et al.
Intrapatient variability of serial steady-state plasma tricyclic antidepressant concentrations
J Pharm Sci
(1978) - et al.
Effects of imipramine hydrochloride on electrophysiological properties of sheep cardiac Purkinje fibers (abstr)
Am J Cardiol
(1978) - et al.
Electrophysiology and pharmacology of cardiac arrhythmias. II. Relationship of normal and abnormal electrical activity of cardiac fibers to the genesis of arrhythmias B. Reentry—Section 1
Am Heart J
(1974) A review of the cardiovascular effects and toxicity of tricyclic antidepressants
Psychosom Med
(1975)Cardiovascular Effects of Mood-Altering Drugs
- et al.
ECG changes during amitryptyline treatment
Am J Psychiatry
(1963) - et al.
Cardiovascular effects of tricyclic and tetracyclic antidepressants
JAMA
(1978) - et al.
Circulatory effects in man of nortriptyline, a tricyclic antidepressant drug
Pharmacol Clin
(1970) - et al.
Amitriptyline and heart block (letter)
Br Med J
(1967) - et al.
Imipramine-induced heart block: a longitudinal case study
JAMA
(1975)
The effect of toxic and therapeutic doses of tricyclic antidepressant drugs on intracardiac conduction
Eur J Cardiol
The cardiac effects of therapeutic plasma concentrations of imipramine
Am J Psychiatry
A method of monitoring drugs for adverse reactions. II. Amitriptyline and heart disease
Eur J Clin Pharmacol
Cardiac antiarrhythmic effect of imipramine hydrochloride
N Engl J Med
Assessment of cardiovascular side effects of therapeutic doses of tricyclic antidepressant drugs
Aust NZ J Med
Tricyclic antidepressant overdosage: clinical presentation and plasma levels
Clin Pharmacol Ther
Tricyclic antidepressant levels and adverse effects after overdosage
Clin Pharmacol Ther
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Effects of selected tricyclic antidepressants on early-life stages of common carp (Cyprinus carpio)
2017, ChemosphereCitation Excerpt :Among all of the serious adverse effects of TCAs that have been described above, cardiotoxicity is suggested to be the main cause of the increased mortality observed in the exposed groups in our study. The cardiotoxicity of TCAs could be the result of various mechanisms, such as sinus tachycardia or slowing of the depolarization of the cardiac action potential by inhibition of the sodium current and the delayed propagation of depolarization through both the myocardium and conducting tissue, which result in prolongation of the QRS complex and PR/QT intervals and could be the reason for heart failure (Brennan, 1980; Kerr et al., 2001). Increasing mortality during and after hatching and at the start of external feeding suggests that fish are particularly sensitive to toxicants in these developmental phases.
Specific prediction of clinical QT prolongation by kinetic image cytometry in human stem cell derived cardiomyocytes
2016, Journal of Pharmacological and Toxicological MethodsCitation Excerpt :Four of these (chlorpromazine, amitriptyline, desipramine, imipramine) are of the same drug class, tricyclic antidepressants. This suggests that measurement of duration change alone in conjunction with the iPSC derived cardiomyocytes may not be an appropriate assay for this class of compounds, which are observed to slow intraventricular conduction of the action potential in concordance with prolongation of QT interval (Ansel, Coyne, Arnold, & Nelson, 1993; Brennan, 1980; Pacher & Kecskemeti, 2004). In agreement with sodium channel blocking activity, known to occur with tricyclic antidepressant compounds and consistent with conduction slowing, we observed an increase in calcium transient rise time (Fig. 6B) by 21%, 23%, 17%, and 39%, respectively, as well as a reduction of spontaneous beat rate of the cardiomyocytes (by 17%, 23%, 21%, and 11%, respectively) followed by cessation of beating activity at the highest doses of these tricyclic antidepressant compounds.
Amitriptyline inhibits the G protein and K<sup>+</sup> channel in the cloned thyroid cell line
1996, European Journal of PharmacologyEffects of (S)-nafenodone, a new antidepressant, in isolated guinea-pig atrial and ventricular muscle fibres
1991, European Journal of PharmacologyThe cardio-protective features of tricyclic antidepressants
1989, General PharmacologyEfficacy of the antidepressant iprindole against experimental arrhythmias
1986, European Journal of Pharmacology
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This study was supported by the Ontario Heart Foundation, Toronto, Ontario, Canada.